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The retired neurosurgeon's nomination raised eyebrows, given his lack of experience in the field, but the Senate voted 58-41 to confirm him.
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As the president-elect has named his Cabinet picks, in the realm of domestic policy, it's clear he's aiming for a dramatic shift from the Obama administration and tradition.
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The retired neurosurgeon and former GOP presidential candidate is an unorthodox pick to lead the agency that oversees affordable housing programs and enforces fair housing legislation.
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The vice president-elect will replace New Jersey Gov. Chris Christie, as Trump moves quickly to piece together his administration. Christie will stay on as a vice chairman.
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Even before he became "BuzzFeed Andrew," Andrew Kaczynski spent hours a day scouring archives for political research. Now the 26-year-old leads a team bringing controversies and scoops to the public.
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"Even though I might be leaving the campaign trail, you know, there's a lot of people who love me, they just won't vote for me, but it's OK!" he told the CPAC crowd.
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The accomplished neurosurgeon, a surprising presidential candidate, was a top-polling candidate in 2015 before the GOP primary race refocused on national security and foreign affairs.
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The reaper is nearer in the Republican field. The end of the dream may come for any of six candidates who desperately need at least a respectable finish in New Hampshire.
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The billionaire's support remains essentially unchanged at 22 percent, far ahead of other Republican candidates in the state.
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Carson polls high among GOP presidential candidates but fellow African-Americans traditionally are Democrats. Steve Inskeep talks to Republican strategist Ron Christie about primary voting strategies.