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Katko is the third Republican who voted for former President Donald Trump's second impeachment to announce his retirement.
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It was the most members of a president's party to vote for his impeachment in history. Many Republicans faced safety threats ahead of the vote, but Trump had gone too far for this group.
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Rep. Liz Cheney, R-Wyo., is the first member of House GOP leadership to announce publicly support of impeachment. Five other Republican House members also said they'll vote to impeach Trump.
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"I can't defend or explain [Tuesday's] actions or timing of the firing of FBI Director James Comey," said Virginia Rep. Barbara Comstock, who is a top Democratic target in the 2018 midterms.