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CVS will start filling prescriptions for mifepristone in Massachusetts and Rhode Island. Walgreens will start in New York, Pennsylvania, Massachusetts, California and Illinois.
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It could amount to the last round of huge settlements after years of litigation over the industry's role in an overdose crisis linked to more than 500,000 deaths in the U.S. over the past two decades.
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Tuesday's verdict comes as CVS, Walgreens and Walmart face thousands of lawsuits filed by communities across the U.S. The companies say they did nothing wrong dispensing huge quantities of opioids.
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The federal government is offering nursing homes the chance to opt in to the new program, in which pharmacy staff would deliver and administer a future vaccine on site.
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State Attorney General Pam Bondi's office announced Friday that it had added the drugstore chains to a lawsuit filed in May against opioid distributors and manufacturers.